Publications
2023
Zhang J, Pollard AE, Carling D, Viollet B, Ellacott KLJ, Beall C. Pharmacological AMP-activated protein kinase activation suppresses low glucose-dependent macrophage migration inhibitory factor release from macrophages. bioRxiv 2023.10.16.562445; doi: https://doi.org/10.1101/2023.10.16.562445 (pre-print)
Forteath C, Mordi I, Nisr R, Gutierrez-Lara EJ, Alqurashi N, Phair IR, Cameron AR, Beall C, Bahr I, Mohan M, Wong AKF, Dihoum A, Mohammad A, Palmer CNA, Lamont D, Sakamoto K, Viollet B, Foretz M, Lang CC, Rena G. Amino acid homeostasis is a target of metformin therapy. Molecular Metabolism (2023) 74:101750
Firth W, Robb JL, Stewart D, Pye KR, Bamford R, Oguro-Ando A, Beall C, Ellacott KLJ. Regulation of astrocyte metabolism by mitochondrial translocator
protein 18kDa. bioRxiv 2023.09.29.560159; doi: https://doi.org/10.1101/2023.09.29.560159 (pre-print)
MacDonald AJ, Pye KR, Beall C, Ellacott KLJ. Impact of chemogenetic activation of dorsal vagal complex astrocytes in mice on adaptive glucoregulatory responses. Journal of Neuroendocrinology (2023) 35(8).
2022
Ellacott KLJ. Astrocytes in neural circuits controlling appetite and food intake. Current Opinion in Endocrine and Metabolic Research (2022), 22, 100313
Weightman Potter, P.G.; Ellacott, K.L.J.; Randall, A.D.; Beall, C. Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic But Not Cortical Primary Rat Astrocytes. Cells (2022), 11, 3422.
2021
MacDonald AJ, Pye KR, Beall C, Ellacott KLJ. Astrocytes in the dorsal vagal complex are not activated by systemic glucoprivation and their chemogenetic activation does not elicit homeostatic glucoregulatory responses in mice. bioRxiv 2021.12.15.472746; doi: https://doi.org/10.1101/2021.12.15.472746 (pre-print)
Morrissey NA, Beall C, Ellacott KLJ. Absence of the mitochondrial translocator protein 18 kDa in mice does not affect body weight or food intake responses to altered energy availability. Journal of Neuroendocrinology (2021) 33(9).
Weightman Potter PG, Washer S, Jeffries AR, Holley JE, Gutowski NJ, Dempster EL & Beall C. Attenuated Induction of the Unfolded Protein Response In Adult Human Primary Astrocytes in Response to Recurrent Low Glucose. Frontiers in Endocrinology (2021) 12
MacDonald AJ, Yang YHC, Cruz AM, Beall C & Ellacott KLJ. Brain-body control of glucose homeostasis – Insights from model organisms. Frontiers in Endocrinology. (2021) 12(303)
Cruz AM, Partridge KM, Malekizadeh Y, Vlachaki Walker JM, Weightman Potter PG, Pye KR, Shaw SJ, Ellacott KLJ, Beall C. Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats. Frontiers in Endocrinology. (2021) Dec 17;12:697445
Weightman Potter PG, Randall AD, Ellacott KLJ, Beall C. Rat primary hypothalamic, but not cortical, astrocytes increase use of glutamate to fuel metabolism after recurrent low glucose. Endocrine Abstracts (2021) 77 P182
Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG, Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone RD, Langenberg C, Perry JRB, Yeo GS, O’Rahilly S. MC3R links nutritional state to childhood growth and the timing of puberty. Nature 599, 436–441 (2021).
Kelly KP, Ellacott KLJ, Chen H, McGuinness OP, Johnson CH. Time-optimized feeding is beneficial without enforced fasting. Open Biology (2021) 11:210183.
2020
Cruz AM, Beall C. Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance. Frontiers in Physiology 2020. 11:567378. doi: 10.3389/fphys.2020.567378
MacDonald AJ, Ellacott KLJ. Astrocytes in the Nucleus of the Solitary Tract: Contributions to Neural Circuits Controlling Physiology. Physiology & Behaviour. 2020 Jun;112982.doi:10.1016/j.physbeh.2020.112982
MacDonald AJ, Holmes FE, Beall C, Pickering AE, Ellacott KLJ. Regulation of food intake by astrocytes in the brainstem dorsal vagal complex. Glia. 2020 Jun;68(6):1241-1254. doi: 10.1002/glia.23774.
Wall BT, Cruz AM, Otten B, Dunlop MV, Fulford J, Porter C, Abdelrahman DR, Francis SB, Dirks ML. The impact of disuse and high-fat overfeeding on forearm muscle amino acid metabolism in humans. The Journal of Clinical Endocrinology and Metabolism 2020 Apr 18. pii: dgaa184. doi: 10.1210/clinem/dgaa184.
Robb JL, Hammad NA, Weightman Potter PG, Chilton JK, Beall C, Ellacott KLJ. The metabolic response to inflammation in astrocytes is regulated by nuclear factor-kappa B signaling. Glia. 2020 Apr 10. doi: 10.1002/glia.23835.
Hanna L, Kawalek TJ, Beall C, Ellacott KLJ. Changes in neuronal activity across the mouse ventromedial nucleus of the hypothalamus in response to low glucose: Evaluation using an extracellular multi-electrode array approach. Journal of Neuroendocrinology 2020 Mar;32(3):e12824. doi: 10.1111/jne.12824.
Dirks ML, Wall BT, Otten B, Cruz AM, Dunlop MV, Barker AR, Stephens FB. High-fat Overfeeding Does Not Exacerbate Rapid Changes in Forearm Glucose and Fatty Acid Balance During Immobilization. The Journal of Clinical Endocrinology and Metabolism 2020 Jan 1;105(1). pii: dgz049. doi: 10.1210/clinem/dgz049.
2019
Robb JL, Morrissey NA, Weightman Potter PG, Smithers HE, Beall C, Ellacott KLJ. Immunometabolic Changes in Glia - A Potential Role in the Pathophysiology of Obesity and Diabetes. Neuroscience. 2019 Nov 22. pii: S0306-4522(19)30708-0. doi: 10.1016/j.neuroscience.2019.10.021.
MacDonald AJ, Robb JL, Morrissey NA, Beall C, Ellacott KLJ. Astrocytes in neuroendocrine systems: An overview. J Neuroendocrinol. 2019 May;31(5):e12726. doi: 10.1111/jne.12726.
Weightman Potter PG, Vlachaki Walker JM, Robb JL, Chilton JK, Williamson R, Randall AD, Ellacott KLJ, Beall C. Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes. Diabetologia. 2019 Jan;62(1):187-198. doi: 10.1007/s00125-018-4744-6.
2018
Ghamari-Langroudi M, Cakir I, Lippert RN, Sweeney P, Litt MJ, Ellacott KLJ, Cone RD. Regulation of energy rheostasis by the melanocortin-3 receptor. Science Advances. 2018 Aug 22;4(8):eaat0866. doi: 10.1126/sciadv.aat0866.
Logie L, Lees Z, William Allwood J, McDougall G, Beall C, Rena G. Regulation of hepatic glucose production and AMPK by AICAR but not metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1). Diabetes, Obesity and Metabolism (2018) 20(12):2748-2758.
2017
Beall C, Hanna L, Ellacott KLJ. CNS Targets of Adipokines. Comprehensive Physiology. 2017 Sep 12;7(4):1359-1406. doi: 10.1002/cphy.c160045.
Vlachaki Walker JM, Robb JL, Cruz AM, Malhi A, Weightman Potter PG, Ashford MLJ, McCrimmon RJ, Ellacott KLJ, Beall C. AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. Diabetes, Obesity and Metabolism 2017 Jul;19(7):997-1005. doi: 10.1111/dom.12912.
Dadak S*, Beall C*, Vlachaki Walker JM, Soutar MPM, McCrimmon RJ, Ashford MLJ. Oleate induces KATP channel dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge Neuroscience (2017) 346:p39-42. *Equal contribution
Jeffrey N, Richardson S, Beall C, Harries LW. The species origin of the cellular microenvironment influences markers of beta cell fate and function in EndoC-bH1 cells. Experimental Cell Research (2017) 15;361(2):284-291.
2016
Haythorne E, Hamilton DL, Findlay JA, Beall C, McCrimmon RJ, Ashford MLJ. Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology (2016) 111: 212-222.
Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJK, Savinko T, Wong AK, Viollet B, Sakamoto K, Fagerholm SC, Foretz M, Lang CC, Rena G. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circulation Research (2016). 119(5): p.652-665.
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BYH, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O’Dowd JF, Harikumar P, Tóth M, Beall C, Kyriakou T, Parnis J, Sarma D, Wortmann DDJ, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GSH, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JRS, Cawthorne MA, Watkins H, Ashrafian H. Chronic activation of g2 AMPK induces obesity and reduces beta cell function. Cell Metabolism (2016) 23(5):821-36.
2015
Buckman LB, Thompson MM, Lippert RN, Blackwell TS, Yull FE, Ellacott KLJ. Evidence for novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Molecular Metabolism (2015), 4 pp. 58-63 PMID:25685690
2014
Hamilton DL*, Beall C*, Jeromson S, Chevtzoff C, Cuthbertson DL, Ashford ML. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. Journal of Physiological Sciences (2014) 64:13-20.*Equal contribution
Buckman LB, Anderson-Baucum EK, Hasty AH, Ellacott KLJ. Regulation of S100B in white adipose tissue by obesity in mice. Adipocyte (2014), 3(3):215-220, PMID: 25068089
Lippert RN, Ellacott KLJ, Cone RD. Gender specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice. Endocrinology (2014), May; 155(5):1718-27, PMID: 24605830
Buckman LB, Hasty AH, Flaherty DK, Buckman CT, Thompson MM, Matlock BK, Weller K, Ellacott KLJ. Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system. Brain, Behavior and Immunity. (2014), Jan;35:33-42, PMID: 23831150
Buckman LB and Ellacott KLJ. The contribution of hypothalamic macroglia to the regulation of energy homeostasis. Frontiers in Systems Neuroscience (2014) Oct 22;8:212, PMID:25374514
2013
Beall C, Watterson KR, McCrimmon RJ, Ashford ML. AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. Journal of Bioenergetics and Biomembranes (2013) 45:229-241.
Beall C*, Haythorne E*, Fan X, Du Q, Jovanovic S, Sherwin RS, Ashford ML, McCrimmon RJ. Continuous hypothalamic KATP activation blunts glucose counter-regulation in vivo in rats and suppresses KATP conductance in vitro. Diabetologia (2013) 56:2088-2092.*Equal contribution
Thompson MM, Manning HC, Ellacott KLJ. Translocator protein (TSPO) 18kDa expression is regulated in brown and white adipose tissue by obesity. PLoS One (2013), Nov 18;8(11):e79980, PMID:24260329
Pendergast JS, Branecky KL, Yang W, Ellacott KLJ, Niswender KD, Yamazaki S. High-fat diet acutely affects circadian organization and eating behavior. European Journal Neuroscience (2013), Apr;37(8):1350-6, PMID: 23331763
Buckman LB, Thompson MM, Moreno HN, Ellacott KLJ. Regional astrogliosis in the mouse hypothalamus in response to obesity. Journal of Comparative Neurology (2013), Apr 15;521(6):1322-33, PMID: 23047490
Alcendor DJ, Block FE 3rd, Cliffel DE, Daniels JS, Ellacott KLJ, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, McCawley LJ, McLaughlin B, McLean JA, Niswender KD, Pensabene V, Seale KT, Sherrod SD, Sung HJ, Tabb DL, Webb DJ, Wikswo JP. Neurovascular unit on a chip: implications for translational applications. Stem Cell Research and Therapy (2013);4 Suppl 1:S18 PMID: 24564885
2012
Beall C, Hamilton DL, Gallagher J, Logie L, Wright K, Soutar MP, Dadak S, Ashford FB, Haythorne E, Du Q, Jovanovic A, McCrimmon RJ, Ashford ML. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia. (2012) 55(9):2432-44.
Beall C, Ashford ML, McCrimmon RJ. The physiology and pathophysiology of the neural control of the counterregulatory response. American Journal of Physiology, Regulatory, Integrative and Comparative Physiology (2012). 302(2): p. R215-R223.
Ashford M, Beall C, McCrimmon R. Hypoglycaemia: Exercise for the Brain? Journal of Neuroendocrinology (2012) 24(10):1365-66.
Orr JS, Puglisi MJ, Ellacott KLJ, Lumeng CN, Wasserman DH, Hasty AH. Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes (2012), Nov;61(11):2718-27, PMID: 22751700
Renquist BJ, Murphy JG, Larson EA, Olsen D, Klein RF, Ellacott KLJ, Cone RD. Melanocortin-3 receptor regulates the normal fasting response. Proceedings of the National Academy of Sciences (2012), 109(23):E1489-98, PMID:22573815
Hatoum IJ, Stylopoulos N, Vanhoose AM, Boyd KL, Yin DP, Ellacott KLJ, Ma LL, Blaczczyk K, Keogh JM, Cone RD, Farooqi IS, Kaplan LM. Melanocortin-4 receptor signaling is required for weight loss after Roux-en-Y gastric bypass surgery. Journal of Clinical Endocrinology & Metabolism (2012), 97(6):E1023-31, PMID: 22492873
2011
Renquist BJ, Lippert RN, Sebag JA, Ellacott KLJ, Cone RD. Physiological roles of the melanocortin MC3 receptor. European Journal of Pharmacology (2011) 660(1):13-20, PMID: 21211527
Srisai D, Gillum MP, Panaro BL, Zhang XM, Kotchabhakdi N, Shulman GI, Ellacott KLJ, Cone RD. Characterization of the Hyperphagic Response to Dietary Fat in the MC4R Knockout Mouse. Endocrinology (2011), Mar; 152 (3): 890-902, PMID: 21211527
2010 and beyond
Beall C*, Piipare K*, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford MLJ. Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity of hypoglycaemia. Biochemical Journal (2010) 429:323-353.*Equal contribution
Ellacott KLJ, Morton GJ, Woods SC, Tso P, Schwartz MW. Assessment of feeding behavior in laboratory mice. Cell Metabolism (2010); 4; 12(1):10-17, PMID: 20620991